N-acyl amino acid derivatives for treating skin conditions such as cellulite
AssigneeHelix Biomedix, Inc.
InventorsTimothy J. Falla, Lijuan Zhang
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Abstract
The invention relates to small molecules having biological and therapeutic activity. Particularly, the invention relates to small molecules having lipolytic and anti-adipogenic activity. Two examples of such molecules are 4-methyl-2-(octanoylamino) pentanoic acid and N-isopentyloctanamide. The invention further relates to methods of preventing or treating skin conditions such as cellulite using small molecules having lipolytic and anti-adipogenic activity.
Claims20
A composition for use in treating the skin of a mammal, said composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound or pharmaceutically acceptable salts thereof, wherein the compound comprises the formula:
- R1—C(O)—NH—R2;
- wherein
- R1 comprises a chain of 5 to 35 carbon atoms,
- the R1—C(O) portion of the formula is a fatty acyl group, and
- the NH—R2 portion of said formula comprises:
- (i) an amino acid, wherein the R2 group comprises the alpha-carbon, carboxyl group and side group of said amino acid, and wherein the NH group is linked to the alpha-carbon of said amino acid;
- or
- (ii) an analog of said amino acid, wherein said analog differs from said amino acid by lacking the carboxylic group linked to the amino acid alpha-carbon, wherein the R2 group comprises the alpha-carbon and side group of said amino acid, and wherein the NH group is linked to the alpha-carbon of said analog.
Dependencies are inferred from the claim text.