Mesoderm and definitive endoderm cell populations
AssigneeMount Sinai School of Medicine
InventorsGordon M. Keller, Paul Gadue
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Abstract
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy. The present invention further provides a method of generating hepatocytes, cell populations enriched for hepatocytes, and a method of hepatocyte replacement therapy.
Claims11
-29. (canceled)
A method of making a cell population enriched for endoderm cells comprising culturing pluripotent stem cells for a time sufficient to provide brach+/HNF3β+ cells, and culturing said brach+/HNF3β+ cells in the presence of activin or nodal and an inhibitor of Wnt signaling for a time sufficient to provide a cell population enriched for endoderm cells.
Dependencies are inferred from the claim text.