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US 2012/0270293 A1Published application
Standardization of tissue specimen preservation by ultrasound and temperature control
OwnerWei-Sing Chuinventor
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Abstract
A tissue sample preservation process and device for improving and standardizing tissue preservation procedure, including placing tissue specimens in a cold fixative, performing fixative penetration at a refrigerated temperature, and accelerating fixative penetration by ultrasound. Also disclosed is the application of ultrasound and temperature control in the dehydration, clearing, and impregnation steps.
Claims29
A method of preserving tissue specimens comprising:
- a) submerging said tissue specimens into a fixative of a temperature between 0 to 25 degree C.,
- b) subjecting said tissue specimens and said fixative to a cooling mechanism, and,
- c) subjecting said tissue specimens and said fixative to a convection mechanism.
A device for preserving tissue specimens in an ultrasound field, comprising:
- 1) At least one vessel for holding tissue specimens and preservation reagent(s),
- 2) An ultrasound generating system to produce ultrasound field in reagent(s), and
- 3) A temperature control system for maintaining a preset temperature in said vessel.
Dependencies are inferred from the claim text.