Porous materials coated with calcium phosphate and methods of fabrication thereof
AssigneeRegeneration Therapeutic Inc.
InventorsLimin Guan, John E. Davies
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Abstract
The present invention relates to a method of coating a porous material such as a medical implant with a layer of calcium phosphate, wherein the material is submersed in an aqueous solution of calcium, phosphate and carbonate ions, and the pH of the solution is gradually increased. A calcium phosphate coating is formed on an internal surface of the porous material by agitating the solution during coating formation.
Claims64
A method of forming a calcium phosphate coating on internal surface of a porous material, said method comprising the steps of:
- providing an aqueous solution comprising calcium ions, phosphate ions, and carbonate ions, wherein said aqueous solution has a temperature less than approximately 100° C. and an initial pH in a range of approximately 6.0 to 7.5;
- contacting said porous material with said solution;
- and
- agitating said solution while forming said calcium phosphate coating on said internal surface of said porous material.
A material comprising an internally connected porous network, said porous network defined substantially throughout said material, wherein pores forming said porous network are coated with a calcium phosphate layer.
A method of forming a calcium phosphate coating on internal surface of a porous material comprising a composite material formed of a macroporous polymer scaffold and calcium phosphate particles, said method comprising the steps of:
- providing an aqueous solution comprising calcium ions, phosphate ions, and carbonate ions, wherein said aqueous solution has a temperature in a range of approximately 20° C.-50° C. and an initial pH in a range of approximately 6.0-7.5;
- contacting said porous material with said solution;
- and
- stirring said solution at a speed of approximately 200-400 revolutions per minute while forming said calcium phosphate coating on said internal surface of said porous material.
Dependencies are inferred from the claim text.