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US 2012/0269897 A1Published application
Poly(tetrafluoroethylene) polymer with nitric oxide donating surface
AssigneeMedtronic Vascular, Inc.
InventorsMingfei CHEN, Ayala HEZI-YAMIT
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Abstract
Described herein are nitric oxide (NO)-donating poly(tetrafluoroethylene) (PTFE) polymers and polymer surfaces and methods of making and using the same. The NO-donating PTFE polymers can be used to fabricate at least a portion of an implantable medical device, coat at least a portion of an implantable medical device or form at least a portion of an implantable medical device. The NO-donating PTFE polymers provide controlled release of NO once implanted at or within the target site.
Claims6
A nitric oxide donating polymer comprising:
- a poly(tetrafluoroethylene) polymer having the structure:
- wherein n is an integer between 1 and 25,000 and wherein each of R1, R2, R3, and R4 is independently fluorine or a tertiary amine having the structure
- wherein X1 and X2 are each independently O or not present, Y1 and Y2 are each independently selected from C1 to C10 alkyl, C1 to C10 alkenyl, C1 to C10 alkynyl, C3 to C8 cyclic alkyl, or any combination thereof, and each of B1, B2, B3, B4, B5, and B6 is independently hydrogen or a diazeniumdiolate (DD) group, with the proviso that at least one of B1, B2, B3, B4, B5, and B6 is a DD group;
- wherein at least one of R1, R2, R3, and R4 is a tertiary amine of the structure of Formula 2
1 more element
Dependencies are inferred from the claim text.