Gastroretentive Composition On The Basis Of A Water-Soluble Reaction Product From A Vinyl Group-Containing Precursor

A gastroretentive composition comprising a mixture comprising:

• an active ingredient component comprising ibuprofen;
• and
• an excipient component comprising;
• polyvinyl alcohol;
• and
• a graft copolymer of polyethylene glycol and polyvinyl alcohol;
• wherein said active ingredient component is dispersed with said excipient component in the mixture.

A method of forming a gastroretentive composition, said method comprising the steps of:

• providing an active ingredient component in powder form;
• providing an excipient component in powder form comprising;
• a first water-soluble reaction product produced from a precursor comprising a vinyl group;
• and
• a copolymer of a polyalkylene glycol and a second water-soluble reaction product produced from a precursor comprising a vinyl group wherein the first water-soluble reaction product and the second water-soluble reaction product may be the same or different;
• mixing the active ingredient component and the excipient component to form a mixture in powder form;
• aggregating the mixture to form an aggregation;
• dry granulating the aggregation to form a plurality of granules;
• and
• processing the plurality of granules to form the gastroretentive composition.