Toll-like receptor 5 ligands and methods of use
AssigneesUniversity of Washington, Institute for Systems Biology
InventorsAlan Aderem, Fumitaka Hayashi, Kelly D. Smith, David M. Underhill, Adrian Ozinsky
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Abstract
The invention provides methods to elicit an immune response with an immunomodulatory flagellin polypeptide having toll-like receptor 5 (TLR5) binding, and further comprising an ADCC targeting molecule.
Claims9
A method to induce an antigen-specific immune response in an individual comprising administering to said individual an immunogenic amount of an immunogenic composition, said immunogenic composition comprising an antigen and an immunomodulatory flagellin polypeptide that stimulates TLR5 which polypeptide consists of at least a portion of a naturally occurring flagellin protein,
- wherein said portion includes the conserved regions of said flagellin protein,
- wherein said conserved regions are defined as sequences that align with consensus sequence SEQ ID NO:34, and
- wherein said immunomodulatory flagellin polypeptide further comprises an ADCC targeting molecule.
An immunomodulatory flagellin polypeptide that stimulates TLR5 which polypeptide consists of at least a portion of a naturally occurring flagellin protein,
- wherein said portion includes the conserved regions of said flagellin protein,
- wherein said conserved regions are defined as sequences that align with consensus sequence SEQ ID NO:34, and
- wherein said immunomodulatory flagellin polypeptide further comprises an ADCC targeting molecule.
Dependencies are inferred from the claim text.