Conjugates with improved pharmacokinetic properties
OwnerLawrence Horowitz, Ramesh Bhatt +1inventors
InventorsLawrence Horowitz, Ramesh Bhatt, Aaron Kurtzman
Life of this patent
Estimating the term…
Abstract
The present invention concerns methods and means for modulating pharmacokinetic properties of molecules, such as biologically active molecules. More specifically, the present invention concerns conjugates comprising a biologically active moiety and a moiety conjugated to and modulating at least one pharmacokinetic property of the biologically active moiety (pharmacokinetic property modulating moiety).
Claims52
A conjugate comprising a first moiety and a second moiety, wherein the second moiety is a scaffold comprising one or more functionally null binding regions conjugated to and capable of modulating at least one pharmacokinetic property of the first moiety.
A fusion molecule comprising a first moiety and a second moiety, wherein said second moiety comprises one or more functionally null binding regions fused to and capable of modulating at least one pharmacokinetic property of the first moiety.
A method of modulating a pharmacokinetic property of a molecule comprising conjugating said molecule to a moiety comprising at least one functionally null binding region.
Use of a moiety comprising at least one functionally null binding region to modulate the pharmacokinetic property of a molecule.
Dependencies are inferred from the claim text.