Anti-Botulinum Neurotoxin a Single Domain Antibody Antibodies
OwnerJames D. Marks, Jianbo Dong +1inventors
InventorsJames D. Marks, Jianbo Dong, Jianlong Lou
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Abstract
Antibodies that bind to botulinum neurotoxin(s) are disclosed herein, as well as related compositions and methods of use. The present disclosure provides antibodies that specifically bind a Botulinum neurotoxin (BoNT) and inhibit the activity of BoNT in cleavage of its substrate.
Claims13
An isolated antibody that specifically binds a Botulinum neurotoxin (BoNT) and inhibits the activity of BoNT in cleavage of its substrate.
An isolated antibody that specifically binds an epitope of a Botulinum neurotoxin that is specifically bound by an antibody comprising a VH comprising a CDR1, CDR2 and CDR3, wherein the CDR1, CDR2 and CDR3 are independently selected from a CDR1, CDR2 and CDR3 of a VH of an antibody selected from the group consisting of Aa1, A26, A3, A16, A23, A10, Aa12, Aa6, Aa9, A8, A21, A19, Aa8, Aa5, Aa11, A8.1a, B01, B04, B12, B22, Bc1, Bc2, Bc3, Bc4, Bc5, Bc6, Bc7, Bc8, Bc9, Bc10, Bc11, Bc12, Bc13, or Bc14.
An isolated nucleic acid comprising a nucleotide sequence encoding an amino acid sequence of:
- a VH comprising a CDR1, CDR2 and CDR3 of an antibody selected from the group consisting of Aa1, A26, A3, A16, A23, A10, Aa12, Aa6, Aa9, A8, A21, A19, Aa8, Aa5, Aa11, A8.1a, B01, B04, B12, B22, Bc1, Bc2, Bc3, Bc4, Bc5, Bc6, Bc7, Bc8, Bc9, Bc10, Bc11, Bc12, Bc13, or Bc14.
Dependencies are inferred from the claim text.