Stabilized chitosan-based nanoparticles and methods for making the same
AssigneeUniversity of Central Florida Research Foundation, Inc.
InventorsSwadeshmukul Santra, James Turkson, Astha Malhotra, Padmavathy Tallury
Life of this patent
Estimating the term…
Abstract
A stabilized chitosan-based nanoparticle is provided having a chitosan polymer and a hydrophilic dispersing agent. In the stabilized nanoparticle, chains of the chitosan polymer electrostatically interact with chains of the hydrophilic dispersing agent to form an entangled network between the chitosan polymer and the hydrophilic dispersing agent. The stabilized chitosan-based nanoparticle has optimal particle integrity and stability properties under physiological conditions.
Claims20
A stabilized chitosan-based nanoparticle comprising:
- a chitosan polymer;
- and
- a hydrophilic dispersing agent;
- wherein chains of the chitosan polymer electrostatically interact with chains of the hydrophilic dispersing agent to form an entangled network comprising the chitosan polymer and the hydrophilic dispersing agent.
The stabilized chitosan-based nanoparticle of claim, wherein the nanoparticle has a particle size of between about 20 and about 100 nm.
A method for synthesizing stabilized chitosan-based nanoparticles comprising:
- reacting components of a first microemulsion and a second microemulsion for a time sufficient to form a stabilized chitosan-based nanoparticle comprising a chitosan polymer and a hydrophilic dispersing agent, wherein the first microemulsion comprises an oil, a surfactant, and an aqueous phase comprising a chitosan polymer and the second microemulsion comprises an oil, a surfactant, and an aqueous phase comprising a hydrophilic dispersing agent;
- and
- recovering the stabilized chitosan-based nanoparticles from the reacted first and second microemulsion components.
An in vivo imaging method comprising:
- detecting the presence of a stabilized chitosan-based nanoparticle administered to a subject, wherein the stabilized chitosan-based nanoparticle comprises a chitosan polymer and a hydrophilic dispersing agent, and wherein chains of the chitosan polymer electrostatically interact with chains of the hydrophilic dispersing agent to form an entangled network comprising the chitosan polymer and the hydrophilic dispersing agent.
The method of claim 20, wherein said stabilized chitosan-based nanoparticle has been administered by topical, transmucosal, inhalational, or parenteral administration.
Dependencies are inferred from the claim text.