Detection of hepatic insulin resistance
AssigneeAlbert Einstein College of Medicine of Yeshiva University
InventorDavid L. Silver
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Abstract
Disclosed are methods for determining whether a subject may have hepatic insulin resistance, for diagnosing hepatic insulin resistance, and for assessing the prognosis of a subject with hepatic insulin resistance, comprising determining the level of expression of major facilitator superfamily domain 2 protein (Mfsd2) in a subject's liver, where overexpression of Mfsd2 is indicative of hepatic insulin resistance.
Claims20
A method for determining whether a subject may have hepatic insulin resistance comprising determining the level of expression of major facilitator superfamily domain 2 protein (Mfsd2) in the subject's liver or sample thereof, wherein overexpression of Mfsd2 may indicate hepatic insulin resistance or wherein no overexpression of Mfsd2 may indicate a lack of hepatic insulin resistance.
A method for diagnosing hepatic insulin resistance in a subject comprising determining the level of expression of major facilitator superfamily domain 2 protein (Mfsd2) in the subject's liver or sample thereof, wherein overexpression of Mfsd2 indicates increased hepatic insulin resistance or wherein no overexpression of Mfsd2 indicates a lack of hepatic insulin resistance.
A method for assessing the prognosis of a subject with hepatic insulin resistance, the method comprising imaging the subject's liver and/or tissue sample for expression of major facilitator superfamily domain 2 protein (Mfsd2), wherein the subject's prognosis increases with a decrease in expression of Mfsd2 or wherein the subject's prognosis decreases with an increase in expression of Mfsd2.
A kit for detecting expression of Mfsd2, the kit comprising an antibody, an antibody fragment, an aptamer, peptide or small molecule that specifically binds to Mfsd2.
A kit for detecting the presence of Mfsd2 mRNA, the kit comprising a probe that specifically binds to Mfsd2 mRNA.
Dependencies are inferred from the claim text.