Use of K2P Potassium Channel Activators as Antalgics
AssigneeUniversite D'Auvergne Clermont I
InventorsAlain Eschalier, Jéröme Busserolles, Abdelkrim Alloui, Michel Lazdunski
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Abstract
The present invention relates to treating and preventing pain. More particularly the present invention demonstrates the involvement of K2P potassium channels in the antalgic effect of morphine. The present invention therefore provides a screening method for identifying antalgics.
Claims12
A screening method for identifying an antalgic compound without any constipating and/or respiratory depressive effect, carried out in vitro or in vivo on non-human model animals, comprising the following steps:
- a) providing a candidate compound;
- b) determining whether said candidate compound activates a potassium channel selected from TREK-1, TRAAK and TREK-2;
- wherein the determination that said candidate compound activates said potassium channel, indicates that said candidate compound is an antalgic compound without any constipating and/or respiratory depressive effect.
A screening method for identifying an antalgic compound without any constipating and/or respiratory depressive effect comprising the following steps:
- a) identifying an activator of a potassium channel selected from TREK-1, TRAAK and TREK-2 by screening candidate compounds;
- b) measuring the antalgic effect of said activator;
- and optionally
- c) measuring the constipating and/or respiratory depressive effect of said activator.
The use of a potassium channel selected from TREK-1, TRAAK and TREK-2 as a target for identifying an antalgic compound without any constipating and/or respiratory depressive effect during screening of candidate compounds.
A method for manufacturing a drug containing an activator of a potassium channel selected from TRAAK, TREK-1 and TREK-2 comprising the following steps:
- a) producing said drug;
- b) measuring the antalgic effect of said drug;
- and optionally, and
- c) measuring the constipating and/or respiratory depressive effect of said drug.
Dependencies are inferred from the claim text.