Pharmaceutical substances on the basis of mitochondria-addressed antioxidants

A compound of Formula II:

• and the reduced (quinone) form thereof,
• wherein:
• R1 comprises a methyl group;
• R2 and R3 are identical or different substituents selected from lower alkyl or lower alkoxy;
• Link comprises either a straight or branched hydrocarbon chain optionally comprising one or more double or triple bond, an ether bond, an ester bond, a C—S bond, an S—S bond, or a peptide bond;
• Z+ comprises a hydrophobic cation;
• and
• the compound is not MitoQ.

A compound of Formula II:

• and the reduced (quinone) form thereof,
• wherein:
• R1 comprises a methyl group or hydrogen,
• R2, or R3, or both are hydrogen;
• Link comprises either a straight or branched hydrocarbon chain optionally comprising one or more double or triple bond, an ether bond, an ester bond, a C—S bond, an S—S bond, or a peptide bond;
• Z+ comprises a hydrophobic cation;
• and
• the compound is not DMQ.

A compound of Formula II:

• and the reduced (quinone) form thereof,
• wherein:
• R1 is methyl or hydrogen;
• R2 and R3 are identical or different substituents selected from lower alkyl or lower alkoxy, at least one of R2 or R3 being lower alkyl;
• Link comprises either a straight or branched hydrocarbon chain optionally comprising one or more double or triple bond, an ether bond, an ester bond, a C—S bond, an S—S bond, or a peptide bond;
• Z+ comprises a hydrophobic cation;
• and
• the compound is not SkQR1, SkQ3, SkQ4, SkQ5, or SkQ1.

A compound of Formula IX:

• and the reduced (quinone) form thereof,
• wherein:
• m is an integer from 0 to 3;
• and
• L is a linker comprising from about 1 to about 50 units, each unit comprising:
• a straight or branched hydrocarbon chain optionally containing one or more double or triple bond, ether bond, ester bond, C—S bond, S—S bond, or peptide bond;
• and which is optionally substituted by one or more substituents selected from the group consisting of alkyl, alkoxy, halogen, keto group, and amino group;
• or
• a natural isoprene chain.