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US 2012/0259022 A1Published application
Pharmaceutical compositions providing enhanced drug concentrations
AssigneeBend Research, Inc.
InventorsWilliam J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
Life of this patent
Estimating the term…
Abstract
A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
Claims10
A composition comprising:
- (a) a drug in a pharmaceutically acceptable solubility-improved form that is a high-energy crystalline form of said drug;
- and
- (b) a concentration-enhancing polymer selected from the group consisting of cellulose acetate phthalate, cellulose acetate trimellitate, hydroxypropyl methyl cellulose phthalate, and hydroxypropyl methyl cellulose acetate succinate hydroxypropyl methyl cellulose acetate, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, methyl cellulose, hydroxyethyl methyl cellulose, hydroxyethyl cellulose acetate, hydroxyethyl ethyl cellulose, carboxymethyl ethyl cellulose, acrylate and methacrylate copolymers, and mixtures thereof
- wherein
- said drug alone has an aqueous solubility of up to 2 mg/mL at pH 1 to 8, and said composition is not a dispersion.
2 more elements
A composition comprising:
- (a) a drug in a pharmaceutically acceptable solubility-improved form that is a solution of said drug substantially dissolved in a liquid to a concentration that is at least 10-fold the equilibrium concentration of said drug in a use environment;
- and
- (b) a concentration-enhancing polymer selected from the group consisting of cellulose acetate phthalate, cellulose acetate trimellitate, hydroxypropyl methyl cellulose phthalate, and hydroxypropyl methyl cellulose acetate succinate hydroxypropyl methyl cellulose acetate, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, methyl cellulose, hydroxyethyl methyl cellulose, hydroxyethyl cellulose acetate, hydroxyethyl ethyl cellulose, carboxymethyl ethyl cellulose, acrylate and methacrylate copolymers, and mixtures thereof
- wherein
- said drug alone has an aqueous solubility of up to 2 mg/mL at pH 1 to 8, and said composition is not a dispersion.
2 more elements
A composition comprising:
- (a) a drug in a pharmaceutically acceptable solubility-improved form that is a composition comprising a mixture of said drug and a solubilizing agent selected from the group consisting of surfactants, pH control agents, glycerides, partial glycerides, glyceride derivatives, polyoxyethylene and polyoxypropylene ethers and their copolymers, sorbitan esters, polyoxyethylene sorbitan esters, alkyl sulfonates, and cyclodextrins;
- and
- (b) a concentration-enhancing polymer selected from the group consisting of cellulose acetate phthalate, cellulose acetate trimellitate, hydroxypropyl methyl cellulose phthalate, and hydroxypropyl methyl cellulose acetate succinate hydroxypropyl methyl cellulose acetate, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, methyl cellulose, hydroxyethyl methyl cellulose, hydroxyethyl cellulose acetate, hydroxyethyl ethyl cellulose, carboxymethyl ethyl cellulose, acrylate and methacrylate copolymers, and mixtures thereof
- wherein
- said drug alone has an aqueous solubility of up to 2 mg/mL at pH 1 to 8, said composition is not a dispersion and said drug and said polymer are present as particles in a dry physical mixture.
2 more elements
Dependencies are inferred from the claim text.