Targeting Estrogen Receptors in the Treatment of Lymphangioleiomyomatosis
AssigneeFox Chase Cancer Center
InventorsElizabeth P. Henske, Jane Yu
Life of this patent
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Abstract
Methods for inhibiting estrogen hormone-induced pulmonary metastasis of smooth muscle cells that are capable of pulmonary metastasis comprise antagonizing the estradiol receptor on the smooth muscle cells such that pulmonary metastasis of the cells is inhibited.
Claims20
A method for treating lymphangioleiomyomatosis (LAM), comprising administering to a subject in need thereof Fulvestrant or a pharmaceutically acceptable salt thereof in an amount effective to treat LAM.
A method for inhibiting estrogen hormone-induced pulmonary metastasis of smooth muscle cells capable of pulmonary metastasis, comprising antagonizing an estrogen receptor on the smooth muscle cells such that pulmonary metastasis of the cells is inhibited.
A kit for treating lymphangioleiomyomatosis (LAM), comprising a composition comprising a pharmaceutically acceptable carrier and an amount of Fulvestrant or a pharmaceutically acceptable salt thereof effective to treat LAM, and instructions for using the kit in a method for treating LAM.
Dependencies are inferred from the claim text.