Indicator agent for noninflammatory stress response and use thereof

A method of measuring the degree of stress response, which comprises detecting a first visualizing agent that binds active type IL-18 in blood and a second visualizing agent that binds phosphorylated P38MAP kinase in adrenal gland,

• wherein
• the first visualizing agent comprises an IL-18 antibody specifically recognizing active type IL-18 and the second visualizing agent comprises an anti-phosphorylated P38MAP kinase antibody, and
• the degree of binding detected correlates to the degree of stress response.

A method of measuring the degree of stress response, which comprises detecting a first visualizing agent that binds active type IL-18 in blood and a second visualizing agent that binds at least one of the proteins selected from the group consisting of phosphorylated P38MAP kinase in adrenal gland, caspase-11, caspase-1 and activated caspase-1,

• wherein
• the first visualizing agent comprises an IL-18 antibody specifically recognizing active type IL-18 and the second visualizing agent comprises at least one of the compounds selected from the group consisting of an anti-phosphorylated P38MAP kinase antibody, a caspase-11 antibody, a caspase-1 antibody, a caspase-1 antibody specifically recognizing activated caspase-1, and a caspase-1 substrate, and
• the degree of binding detected correlates to the degree of stress response.