Tyrosine Kinase Microspheres
AssigneeAllergan, Inc.
InventorsPatrick M. Hughes, Christian Sarrazin, Elisabeth Rossi, Michele Boix
Life of this patent
Estimating the term…
Abstract
Biocompatible intraocular microspheres include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the microspheres can be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The microspheres can be placed into an eye to treat or reduce the occurrence of one or more ocular conditions.
Claims11
-4. (canceled)
A process for making biodegradable active agent microspheres, the process comprising the steps of:
- (a) preparing an organic phase, which comprises, an active agent, a biodegradable polymer, and a solvent for the active agent and the polymer;
- (b) preparing a first aqueous phase;
- (c) combining the organic and the aqueous phase to form an emulsion;
- (d) preparing a second aqueous phase;
- (e) adding the second aqueous phase to the emulsion to form a solution
- (f) stirring the solution, and;
- (g) evaporating the solvent, thereby making biodegradable active agent microspheres.
A process for making biodegradable active agent microspheres, the process comprising the steps of:
- (a) preparing a viscous organic phase, which comprises an active agent, a biodegradable PLGA polymer, and a solvent for the active agent and the PLGA polymer;
- (b) crystallizing active agent in the viscous organic phase
- (c) preparing a first aqueous phase with a pH between about pH 6 and about pH 8;
- (d) combining the organic and the aqueous phase to form an emulsion;
- (e) crystallizing active agent in the emulsion;
- (f) preparing a second aqueous phase with a pH between about pH 4 and about pH 9;
- (g) adding the second aqueous phase to the emulsion to form a solution
- (h) stirring the solution, and;
- (i) evaporating the solvent, thereby making biodegradable active agent microspheres.
(canceled)
-17. (canceled)
Dependencies are inferred from the claim text.