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US 2012/0258142 A1Published application
Glycolipids and analogues thereof as antigens for nkt cells
AssigneesThe Scripps Research Institute, The Rockefeller University
InventorsMoriya TSUJI, David D. HO, Chi-Huey WONG, Douglass WU, Masakazu FUJIO, Xiangming LI
Life of this patent
Estimating the term…
Abstract
This invention relates to immunogenic compounds which serve as ligands for NKT (natural killer T) cells and to methods of use thereof in modulating immune responses.
Claims21
1-40. (canceled)
A method for modulating an immune response in a subject, the method comprising steps:
- (a) administering to the subject a compound, composition, or vaccine, wherein the compound, composition, or vaccine, comprises an adjuvant, wherein the adjuvant comprises a compound represented by the structure of formula 1:
- wherein, R═COOR1 or CH2OR1;
- R1═H or an alkyl group;
- R2═H or SO3−;
- R3═H or OH;
- R3′═H or OH;
- R4 and R4′ are independently chosen from
- (a) H,
- (b) alkyl;
- (c) alkenyl;
- and
- (d) oxaalkyl;
- R5═OH, acetamido or a halogen atom;
- or a pharmaceutically acceptable salt thereof,
- wherein if R═CH2OR1 where R1 is H, then R2═SO3−, and
- wherein if R═CH2OR1, R2═H, R3 is OH and R3′ is H, then
- R5=acetamido or a halogen atom;
- Or
- a compound represented by the structure of formula (17):
- wherein
- R4 is selected from:
- (a) alkyl,
- (b) alkenyl,
- (c) alkyl terminating in aryl, substituted aryl, heteroaryl or substituted heteroaryl;
- and
- (d) alkenyl terminating in aryl, substituted aryl, heteroaryl or substituted heteroaryl, and
- R6 is
- X is an alkyl chain;
- and
- R7 is chosen from halogen, H, phenyl, alkyl, alkoxy, nitro, and CF3.
27 more elements
A method for stimulating an immune response in a subject, the method comprising steps:
- (a) administering to the subject a compound, composition, or vaccine, wherein the compound, composition, or vaccine, comprises an adjuvant, wherein the adjuvant comprises a compound represented by the structure of formula 1:
- wherein, R═COOR1 or CH2OR1;
- R1═H or an alkyl group;
- R2═H or SO3−;
- R3═H or OH;
- R3′═H or OH;
- R4 and R4′ are independently chosen from
- (a) H,
- (b) alkyl;
- (c) alkenyl;
- and
- (d) oxaalkyl;
- R5═OH, acetamido or a halogen atom;
- or a pharmaceutically acceptable salt thereof,
- wherein if R═CH2OR1 where R1 is H, then R2═SO3−, and
- wherein if R═CH2OR1, R2═H, R3 is OH and R3′ is H, then
- R5=acetamido or a halogen atom;
- Or
- a compound represented by the structure of formula (17):
- wherein
- R4 is selected from:
- (a) alkyl,
- (b) alkenyl,
- (c) alkyl terminating in aryl, substituted aryl, heteroaryl or substituted heteroaryl;
- and
- (d) alkenyl terminating in aryl, substituted aryl, heteroaryl or substituted heteroaryl, and
- R6 is
- X is an alkyl chain;
- and
- R7 is chosen from halogen, H, phenyl, alkyl, alkoxy, nitro, and CF3.
27 more elements
A method for inhibiting or suppressing an immune response in a subject, the method comprising steps:
- (a) administering to the subject a compound, composition, or vaccine, wherein the compound, composition, or vaccine, comprises an adjuvant, wherein the adjuvant comprises a compound represented by the structure of formula 1:
- wherein, R═COOR1 or CH2OR1;
- R1═H or an alkyl group;
- R2═H or SO3−;
- R3═H or OH;
- R3′═H or OH;
- R4 and R4′ are independently chosen from
- (a) H,
- (b) alkyl;
- (c) alkenyl;
- and
- (d) oxaalkyl;
- R5<OH, acetamido or a halogen atom;
- or a pharmaceutically acceptable salt thereof,
- wherein if R═CH2OR1 where R1 is H, then R2═SO3−, and
- wherein if R═CH2OR1, R2═H, R3 is OH and R3′ is H, then
- R5=acetamido or a halogen atom;
- Or
- a compound represented by the structure of formula (17):
- wherein
- R4 is selected from:
- (a) alkyl,
- (b) alkenyl,
- (c) alkyl terminating in aryl, substituted aryl, heteroaryl or substituted heteroaryl;
- and
- (d) alkenyl terminating in aryl, substituted aryl, heteroaryl or substituted heteroaryl, and
- R6 is
- X is an alkyl chain;
- and
- R7 is chosen from halogen, H, phenyl, alkyl, alkoxy, nitro, and CF3.
27 more elements
Dependencies are inferred from the claim text.