Immunogenic compositions comprising nanoemulsion and hepatitis b virus immunogen and methods of using the same
AssigneeThe Regents of the University of Michigan
InventorsJames R. Baker, JR., Douglas Smith, Paul E. Makidon
Life of this patent
Estimating the term…
Abstract
The invention provides immunogenic compositions and methods of using the same to induce immune responses (e.g., humoral, mucosal, and/or cell-mediated immune responses) against Hepatitis B virus (HBV)). Compositions and methods of the invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination (e.g., of patient populations at risk for acute and/or chronic HBV infection))) and research applications.
Claims19
An immunogenic composition comprising a nanoemulsion containing about 5-8% by volume Poloxamer, about 8% by volume ethanol, about 1% by volume cetylpyridium chloride (CPC), about 21% by volume water and about 64% by volume soybean oil, and hepatitis B virus (HBV) surface antigen (HBsAg).
A method of inducing a HBsAg-specific immune response in a subject comprising nasally administering an immunogenic composition comprising a nanoemulsion containing about 6% by volume Poloxamer 407, about 8% by volume ethanol, about 1% by volume cetylpyridium chloride (CPC), about 21% by volume water and about 64% by volume soybean oil, and hepatitis B virus (HBV) surface antigen (HBsAg), to a subject in need thereof under conditions such that the subject generates an HBsAg-specific immune response.
Dependencies are inferred from the claim text.