Abuse resistant transdermal drug delivery patch including a release-enhanced antagonist

A transdermal drug delivery patch for the delivery of a drug across the skin of a user comprising:

• a main body providing an occlusive covering on the skin of a user, including:
• an outer face;
• an inner face in combination with said outer face forming a hollow cavity below said inner face;
• a hollow core being formed between said outer and inner faces;
• a plurality of parallel elongated cilia projecting from said inner face into said hollow cavity, said plurality of cilia being spaced apart and each having a diameter along their lengths ranging from 0.01 mm to 1.0 mm, and a hollow tubular core extending from the hollow core formed between said outer and inner faces;
• an excipient matrix filling portions of said cavity between said plurality of parallel elongated cilia;
• an agonist contained in said matrix between said plurality of elongated cilia, respectively;
• an unencapsulated antagonist being contained both within the hollow tubular core of each of said plurality of cilia, respectively, and within the hollow core between said outer and inner faces, respectively;
• a surfactant being contained both within the hollow tubular core of each of said plurality of cilia, respectively, and within the hollow core between said outer and 2.1 inner faces, respectively, whereby during normal use of said patch said excipient matrix is free of said antagonist and surfactant;
• said surfactant being intimately associated with said antagonist and present in a sufficient amount to enhance immediate diffusion of the antagonist throughout said matrix only upon rupture or dissolvement of the plurality of said cilia;
• and
• said plurality of cilia being rigid, and having thinner walls than the walls of said outer face, whereby only upon rupture or dissolvement of said plurality of cilia by an abuser, said cilia will release their associated antagonist and surfactant to block the desired effect an abuser is attempting to obtain by concentrating said agonist to ingest it orally or through injection;
• and
• means for securing said main body to a desired location on the skin of a user.