Back to results
US 2012/0238778 A1Published application
Process for preparing cinacalcet
AssigneeZach System S.P.A.
InventorsNicola Catozzi, Livius Cotarca, Johnny Foletto, Massimiliano Forcato, Roberto Giovanetti, Giorgio Soriato, Massimo Verzini
Life of this patent
Estimating the term…
Abstract
A process for preparing N-[(1R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)-phenyl]propan-1-amine of formula hydrochloride salt of formula (I) i.e. Cinacalcet.HCl and its intermediate of formula (IX)
Claims18
Cinacalcet intermediate having the following formula (X)
A process for preparing Cinacalcet hydrochloride of formula (I)
- which comprises the steps of:
- i) reducing the compound of formula (V)
- to give the compound of formula (IX)
- ii) treating the compound of formula (IX) with a chlorinating agent selected from the group comprising thionyl chloride (SOCl2), phosphorous pentachloride (PCl5), phosphorous oxychloride (POCl3), oxalyl chloride ((ClCO)2), gaseous hydrochloric acid, phosgene (Cl2CO), and non-gaseous oligomeric equivalents of phosgene such as trichloromethyl chloroformate (diphosgene, liquid) and bis(trichloromethyl)carbonate (triphosgene, BTC, solid), which act as phosgene source in situ., to give the compound of formula (X), which can be in admixture with the compound of formula (XI), and
- iii) converting the compound of formula (X) or, if the case, the compound of formula (X) mixed with the compound of formula (XI) into Cinacalcet hydrochloride of formula (I).
2 more elements
Dependencies are inferred from the claim text.