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US 2012/0238552 A1Published application
Pharmaceutical compositions comprising sorbitan esters
AssigneeAlkermes, Inc.
InventorsJason M. PERRY, Daniel R. DEAVER, Magall B. HICKEY, Julius F. REMENAR, Jennifer VANDIVER
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Abstract
The present invention relates to a pharmaceutical composition comprising sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.
Claims40
A pharmaceutical composition comprising:
- (a) a water-insoluble antipsychotic agent;
- (b) sorbitan esters of a carboxylic acid, wherein the carboxylic acid comprises 4-20 carbon atoms;
- (c) a polyoxyethylene derivative of a sorbitan ester of a carboxylic acid, wherein the carboxylic acid comprises 8-14 carbon atoms;
- and
- (d) an aqueous vehicle;
- wherein the composition forms an aqueous, flocculated, injectable suspension.
3 more elements
(canceled)
An injectable pharmaceutical composition comprising:
- (a) aripiprazole, or olanzapine, or a compound of formula I, II, III, IV or V, or pharmaceutically acceptable salts, hydrates, or solvates thereof, wherein component (a) is in a weight ratio of approximately 15-35%;
- (b) sorbitan laurate in a weight ratio of approximately 0.2-1%
- (c) polysorbate 20 in a weight ratio of approximately 0.05-0.8%;
- and
- (d) an aqueous carrier.
2 more elements
An injectable composition comprising a water-insoluble antipsychotic agent and sorbitan esters of a carboxylic acid, wherein the carboxylic acid comprises 8-14 carbon atoms.
Dependencies are inferred from the claim text.