US 2012/0238528 A1 · NOVEL PHOSPHONIC ACID COMPOUNDS AS INHIBITORS OF SERINE PROTEASES

Novel phosphonic acid compounds as inhibitors of serine proteases

AssigneeOrtho-McNeil Pharmaceutical, Inc.

InventorsMichael N. Greco, Harold R. Almond, JR., Lawrence de Garavilla, Michael J. Hawkins, Michael J. Humora, Yun Qian, Donald Gilmore Walker, Sergio Cesco-Cancian, Christopher Norman Nilsen, Mitul N. Patel, Kirk Leonard Sorgi, Eugene Powell

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Abstract

The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.

Claims5

Dependent claims

A compound 35 having the structure:

Dependencies are inferred from the claim text.

Facts

Application

13/471,876Filed 15 May 2012

Priority

19 Oct 2001

Published

20 Sep 2012

Term ends

Not estimatedThe source records don’t support an estimate.

Classification23 codes

C07F 9/65586
Containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common…: at…
A61P 9/10
Drugs for disorders of the cardiovascular system: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary…
A61P 9/12
Drugs for disorders of the cardiovascular system: antihypertensives
A61P 11/00
Drugs for disorders of the respiratory system

Family

Application60/330,343Us provisional application · filed 19 Oct 2001

Application10/273,208Continuation in part · filed 17 Oct 2002

Application10/414,782Division · filed 16 Apr 2003

Application12/290,027Division · filed 24 Oct 2008

Application12/972,891Division · filed 20 Dec 2010

Application13/471,876Division

Application10/414,782Continuation in part

US 2003/0195172 A1Published application

US 2004/0082544 A1Published application

US 2009/0131671 A1Published application

US 2011/0092457 A1Published application

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US 2012/0238528 A1This patent

From the US filing history. Foreign family members aren’t listed.