US 2012/0238509 A1 · UROCORTIN 2 ANALOGS AND USES THEREOF

Abstract

Disclosed are polypeptides that are analogs of urocortin 2 that have pharmacological activity similar to urocortin 2 but have improved water solubility compared to urocortin 2, and pharmaceutical compositions of the polypeptides of the present invention. Also disclosed are polynucleotides encoding the polypeptides, and methods of treating pathophysiological states employing pharmaceutical compositions of the polypeptides and polynucleotides of the present invention. In addition, disclosed are vectors and host cells that include a nucleic acid encoding a polypeptide of the present invention, and kits that include pharmaceutical compositions of the present invention.

Claims36

Dependent claims

An isolated polypeptide of formula (I):

X1—X2—X3—X4—X5—X6 (I)
wherein X1 is either absent or a polypeptide having 1-200 residues;
X2 is absent or 1-20 amino acid residues that are each individually selected from either arginine (R) or lysine (K);
X3 is SEQ ID NO:1, SEQ ID NO:19, SEQ ID NO:21, or SEQ ID NO:22;
X4 is either absent, G, GH, or GHC;
X5 is absent or 1-20 amino acid residues that are each individually selected from either arginine (R) or lysine (K);
X6 is either absent or a polypeptide having 1-200 residues;
provided that if X3 is SEQ ID NO:1, X4, X5, and X6 are all absent, then X2 is not absent;
further provided that if X3 is SEQ ID NO:19, X5 is absent, and X6 is absent, then X4 is G, GH, or GHC.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/392,828Filed 27 Aug 2010

Priority

28 Aug 2009

Published

20 Sep 2012

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61K 38/2228
Hormones: corticotropin releasing factor [CRF]
A61P 3/00
Drugs for disorders of the metabolism
A61P 9/04
Drugs for disorders of the cardiovascular system: inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A61P 25/22
Drugs for disorders of the nervous system: anxiolytics

Urocortin 2 analogs and uses thereof

Life of this patent

Urocortin 2 analogs and uses thereof

Life of this patent

Abstract

Claims36