Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents
AssigneeThe Johns Hopkins University
InventorsAdam Ian Kaplin, Mark T. Worthington
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Abstract
The present invention provides compositions and methods for treating and/or preventing an autoimmune disease comprising administering to a subject in need thereof an effective amount of cyclophosphamide and/or a cyclophosphamide derivative in combination with an additional immunomodulatory agent.
Claims31
A method for treating or preventing an autoimmune disease, the method comprising administering to a subject in need thereof:
- a) a lymphablative agent selected from the group consisting of cyclophosphamide and a cyclophosphamide derivative;
- and
- b) an additional immunomodulatory agent selected from the group consisting of an amino acid co-polymer, a peptide fragment of myelin basic protein, an anti-tumor necrosis factor agent and pharmaceutically acceptable salts thereof;
- wherein the autoimmune disease selected from the group consisting of inflammatory bowel disease, rheumatoid arthritis, diabetes mellitus, celiac disease, autoimmune thyroid disease, autoimmune liver disease, Addison's Disease, Sjögren's Syndrome, transplant rejection, graft vs. host disease and host vs. graft disease.
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A composition comprising (a) an effective amount of cyclophosphamide or a cyclophosphamide derivative;
- and (b) an additional immunomodulatory agent selected from the group consisting of an amino acid co-polymer, a peptide fragment of myelin basic protein, an anti-tumor necrosis factor agent, an anti-lymphocyte antibody and pharmaceutically acceptable salts, solvates and isomers thereof, in an effective amount to prevent or treat an autoimmune disease in a subject.
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Dependencies are inferred from the claim text.