Packaging formulation for preventing the insolubility of chitosan-containing compositions
AssigneeHalosource, Inc.
InventorsEverett J. Nichols, James R. Scott, John P. Carroll
Life of this patent
Estimating the term…
Abstract
Formulations, methods, and products for preventing or decreasing insolubilization of chitosan-containing compositions are provided. By employing embodiments discussed herein, the ability of a chitosan-containing composition to properly solubilize at a desired time may be preserved.
Claims37
A formulation comprising:
- a) a chitosan-containing composition chosen from:
- a chitosan salt;
- a blend of (1) a solid chitosan that may be partially protonated but is greater than 80% insoluble when added to water and in a dry, free-flowing, particulate form, and (2) a solid acid or a solid agent that generates a proton in situ in the presence of water;
- and
- a chitosan derivative, and
- b) a desiccant in an amount sufficient to prevent or decrease insolubilization of the chitosan-containing composition.
A sealed moisture-resistant container comprising:
- a formulation comprising a chitosan-containing composition and a desiccant,
- wherein the chitosan-containing composition is chosen from:
- a chitosan salt;
- a blend of (1) a solid chitosan that may be partially protonated but is greater than 80% insoluble when added to water and in a dry, free-flowing, particulate form, and (2) a solid acid or a solid agent that generates a proton in situ in the presence of water;
- and
- a chitosan derivative, and
- wherein the amount of desiccant is sufficient to prevent or decrease insolubilization of the chitosan-containing composition.
A method of preventing or decreasing insolubilization of a chitosan-containing composition, the method comprising:
- placing a desiccant in a moisture-resistant container with a chitosan-containing composition,
- wherein the chitosan-containing composition is chosen from:
- a chitosan salt;
- a blend of (1) a solid chitosan that may be partially protonated but is greater than 80% insoluble when added to water and in a dry, free-flowing, particulate form, and (2) a solid acid or a solid agent that generates a proton in situ in the presence of water;
- and
- a chitosan derivative, and
- wherein the amount of desiccant is sufficient to prevent or decrease insolubilization of the chitosan-containing composition.
A method of solubilizing a chitosan-containing composition, comprising:
- a) opening a sealed moisture-resistant container comprising a formulation comprising the chitosan-containing composition and a desiccant,
- wherein the chitosan-containing composition is chosen from:
- a chitosan salt;
- a blend of (1) a solid chitosan that may be partially protonated but is greater than 80% insoluble when added to water and in a dry, free-flowing, particulate form, and (2) a solid acid or a solid agent that generates a proton in situ in the presence of water;
- and
- a chitosan derivative, and
- wherein the amount of desiccant is sufficient to prevent or decrease insolubilization of the chitosan-containing composition, and
- b) exposing the chitosan-containing composition to water to solubilize the chitosan-containing composition.
A method of desiccating a formulation comprising a chitosan-containing composition, the method comprising:
- sealing a formulation comprising the chitosan-containing composition and a desiccant in a moisture-resistant container,
- wherein the chitosan-containing composition is chosen from:
- a chitosan salt;
- a blend of (1) a solid chitosan that may be partially protonated but is greater than 80% insoluble when added to water and in a dry, free-flowing, particulate form, and (2) a solid acid or a solid agent that generates a proton in situ in the presence of water;
- and
- a chitosan derivative, and
- wherein the amount of desiccant is sufficient to prevent or decrease insolubilization of the chitosan-containing composition.
A sealed moisture-resistant container comprising:
- a) a porous device comprising a chitosan-containing composition;
- and
- b) a desiccant.
A formulation comprising:
- a) a chitosan-containing composition chosen from:
- a chitosan salt;
- a blend of (1) a solid chitosan that may be partially protonated but is greater than 80% insoluble when added to water and in a dry, free-flowing, particulate form, and (2) a solid acid or a solid agent that generates a proton in situ in the presence of water;
- and
- a chitosan derivative, and one of b), c), or d):
- b) a Schiff base disruptor;
- c) a monosaccharide reducing sugar;
- or
- d) an amine-containing substance.
A method for preventing or decreasing insolubilization of a chitosan-containing composition, comprising:
- a) reducing moisture within a container to provide a low-moisture container;
- b) placing a chitosan-containing composition within the low-moisture container;
- and
- c) sealing the low-moisture container.
A method of preventing or decreasing insolubilization of a chitosan-containing composition, comprising:
- a) packaging a water soluble chitosan containing composition in a container;
- and
- b) maintaining the composition to a temperature to maintain the water-solubility of the chitosan-containing composition when exposure to ambient temperature would otherwise result in the insolubility of the chitosan-containing composition.
A sealed product containing a chitosan-containing composition, comprising:
- a chitosan-containing composition chosen from:
- a) a chitosan salt;
- b) a blend of (1) a solid chitosan that may be partially protonated but is greater than 80% insoluble when added to water and in a dry, free-flowing, particulate form, and (2) a solid acid or a solid agent that generates a proton in situ in the presence of water;
- and
- c) a chitosan derivative, and
- a moisture content no greater than 10% by weight relative to the weight of the chitosan-containing composition.
A chitosan-containing composition having a moisture content of less than 5% by weight relative to the chitosan-containing composition comprised in a moisture-resistant container.
Dependencies are inferred from the claim text.