Estimating acute response to cardiac resynchronization therapy

A method, comprising:

• measuring, using at least a hemodynamic sensor and another sensor, systolic timing intervals of a plurality of different events of a cardiac cycle, at least one of the systolic timing intervals based on a mechanical cardiac event;
• storing patient population data;
• implementing a fusion algorithm to combine the measured systolic timing intervals of the plurality of different events of the cardiac cycle and the patient population data to compute an estimate of acute responsiveness to cardiac resynchronization therapy (CRT);
• comparing the estimate to a threshold, the threshold distinguishing between acute responsiveness and non-responsiveness to CRT for a patient population;
• and
• producing an indication of acute responsiveness to CRT for a pacing site of a patient's heart in response to the comparison.