Process for the Preparation of (-)-(4-Chloro-Phenyl)-(3-Trifluoromethyl-Phenoxy)-Acetic Acid 2-Acetylamino-Ethyl Ester
AssigneeMetabolex, Inc.
InventorsDiego BROGGINI, Hartmut Burghard Zinser
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Abstract
The present invention is directed to a novel process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester, useful in the treatment of metabolic disorders and further to a process for the preparation of (4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid, a synthesis intermediate.
Claims13
1-57. (canceled)
A compound that is (−)-4-chloro-phenyl-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester having an enantiomeric excess of 99.7% to 99.9%.
A compound that is (−)-4-chloro-phenyl-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester having a chemical purity of 99.1% to 99.6%.
A compound that is (−)-4-chloro-phenyl-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester having an enantiomeric excess of greater than 99.9%.
A compound that is (−)-4-chloro-phenyl-(R)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester having a chemical purity of 99.9%.
A compound that is (−)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid having an enantiomeric excess of 97.5% to 99.5%.
A compound that is (−)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid having a chemical purity of 97.5% to 99.5%.
Dependencies are inferred from the claim text.