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US 2012/0232252 A1Published application
Factor viii polymer conjugates
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsPeter TURECEK, Juergen SIEKMANN
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Abstract
The invention is a proteinaceous construct comprising a Factor VIII molecule which is conjugated to a water-soluble polymer via carbohydrate moieties of Factor VIII, and methods of preparing same.
Claims8
A method of conjugating a water soluble polymer to an oxidized carbohydrate moiety of Factor VIII comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation.
A proteinaceous construct comprising:
- (a) a Factor VIII molecule;
- and
- (b) at least one water soluble polymer bound to said Factor VI I molecule,
- wherein said water soluble polymer is attached to the Factor VIII via one or more carbohydrate moieties located in the B domain Factor VIII.
1 more element
Dependencies are inferred from the claim text.