Use of adrenergic n-phenylpiperazine antagonists, pharmaceutical compositions containing them, and methods of preparing them

A pharmaceutical composition for treating and/or preventing lower urinary tract symptoms in mammals, wherein the lower urinary tract symptoms comprise benign prostatic hyperplasia, the composition comprising:

• a) a compound of formula (I):
• wherein
• R1 is
• X is CH2;
• A is CH2;
• n is 1, 2, 3, or 4;
• R2 is
• wherein W is ortho-alkyloxy, meta-alkyloxy, or para-alkyloxy;
• and
• b) a vehicle, diluent and/or pharmaceutical acceptable excipient.

A method for treating and/or preventing lower urinary tract symptoms in mammals, wherein the lower urinary tract symptoms comprise benign prostatic hyperplasia, comprising providing a therapeutically effective amount to the mammal of a composition selected from the group consisting of:

• 1-benzo[d][1,3]dioxol-5-yl-2-[4-(2-methoxyphenyl)hexahydro-1-pyrazinyl]ethane;
• 1-benzo[d][1,3]dioxol-5-yl-2-[4-(4-methoxyphenyl)hexahydro-1-pyrazinyl]ethane;
• 1-benzo[d][1,3]dioxol-5-yl-3-[4-(2-methoxyphenyl)hexahydro-1-pyrazinyl]propane;
• 1-benzo[d][1,3]dioxol-5-yl-3-[4-(4-methoxyphenyl)hexahydro-1-pyrazinyl]propane;
• 1-benzo[d][1,3]dioxol-5-yl-4-[4-(4-methoxyphenyl)hexahydro-1-pyrazinyl]butane;
• and mixtures thereof.