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US 2012/0232087 A1Published application
Methods and compositions for treating solid tumors and other malignancies
OwnerSilvia Buonamici, Marion Dorsch +1inventors
InventorsSilvia Buonamici, Marion Dorsch, Carlos Garcia-Echeverria
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Abstract
A combination of a kinase inhibitors of mTOR and downstream effector and a hedgehog pathway inhibitor for the treatment of cancer.
Claims11
1-15. (canceled)
A combination comprising a first agent that is a Smoothened inhibitor and a second agent that is an mTOR inhibitor,
- wherein the first agent is 2-[(R)-4-(6-benzyl-4,5-dimethyl-pyridazin-3-yl)-2-methyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyrazinyl-5′-yl]-propan-2-ol or a pharmaceutically acceptable salt thereof.
A method of treating medulloblastoma in a patient in need thereof comprising administering to the patient a first agent that is a Smoothened inhibitor and a second agent that is an mTOR inhibitor,
- wherein the first agent is 2-methyl-4′-trifluoromethoxy-biphenyl-3-carboxylic acid [6-(cis-2,6-dimethyl-morpholin-4-yl)-pyridin-3-yl]-amide or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.