Fused Pyrazine Compounds Useful for the Treatment of Degenerative and Inflammatory Diseases

A compound according to formula IIa, IIb, IIc, IId, IIe, or IIf:

• and wherein Z is N, L is bond, —CO—, SO2, —(CH2)m1—, —O(CH2)m1—, —NH(CH2)m1—, —CON(H)(CH2)m1—, or —SO2NH(CH2)m1—;
• the subscript m1 is selected from 1-4, R8c is independently selected from hydrogen, and substituted or unsubstituted C1-C6 alkyl, and the ring P is substituted or unsubstituted heterocycloalkyl;
• and R9 is independently selected from substituted or unsubstituted aryl and heteroaryl;
• or a pharmaceutically acceptable salt, solvate or prodrug thereof;
• and stereoisomers and tautomers thereof.