Multiuse reactors and related methods
AssigneeTherapeutic Proteins Inc.
InventorSarfaraz K. Niazi
Life of this patent
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Abstract
A septum is positioned within a disposable vessel and defines a lower chamber and an upper chamber. The septum includes a plurality of apertures that provide fluid communication between the upper chamber and lower chamber. Compressed gas is introduced in the lower chamber to produce fine bubbles rising up throughout the vessel to produce a mixing and gasification needed for the growth of a biological culture and manufacture of a biological product in a nutrient medium. Adding a binding resin to the upper chamber allows harvesting, separation and purification of biological products in the reactor as a single unit operation.
Claims93
1) A reactor suitable for housing a predetermined volume of a liquid comprising:
- a) A container having at least one interior wall and an inner volume;
- b) A septum positioned within the container and defining a lower chamber and an upper chamber, the septum having a plurality of pores that provides fluid communication between the lower chamber and the upper chamber;
- c) At least one liquid inlet;
- d) At least one liquid outlet;
- e) At least one gas inlet in fluid communication with a source of compressed gas and located in the lower chamber;
- f) At least one gas outlet in the upper chamber.
Dependencies are inferred from the claim text.