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US 2012/0231076 A1Published application
Pharmaceutical compositions comprising rivaroxaban
Assigneeratiopharm GmbH
InventorsRalph Stefan, Jana Paetz
Life of this patent
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Abstract
The invention relates to pharmaceutical compositions comprising rivaroxaban, suitable for immediate release, and processes of preparing such compositions, preferably by a melt-granulation process or by a specific direct-compression process.
Claims29
A process for producing a pharmaceutical composition, comprising the steps of
- (i) mixing
- a) rivaroxaban,
- b) a matrix former, and
- c) a disintegrant,
- (ii) melting the mixture, and
- (iii) granulating the melted mixture.
3 more elements
A process for producing tablets, comprising the steps of
- (i) mixing
- a) rivaroxaban,
- b) a matrix former,
- c1) a disintegrant, and
- d1) optionally a wicking agent,
- (ii) melting the mixture,
- (iii) granulating the melted mixture,
- (iv) mixing the granulate resulting from step (iii) with
- c2) disintegrant,
- d2) optionally wicking agent, and
- e) optionally further excipients, and
- (v) compressing the mixture resulting from step (iv) into tablets.
9 more elements
A method of using a combination of crospovidone and a wicking agent for producing an immediate release solid oral dosage form containing rivaroxaban.
A process for producing tablets, comprising the steps of
- (i) agglomerating
- a) rivaroxaban,
- b) a solubilizer,
- c1) a disintegrant, and
- d1) a wicking agent, and
- e1) optionally further excipients,
- (ii) mixing the agglomerates resulting from step (i) with
- c2) a disintegrant,
- d2) a wicking agent, and,
- e) optionally, further excipients, and
- (iii) compressing the mixture resulting from step (ii) into tablets.
8 more elements
A tablet comprising
- (I) an inner phase containing
- a) rivaroxaban,
- b) a solubilizer,
- c1) a disintegrant, and
- d1) a wicking agent, and
- e1) optionally, further excipients, and
- (II) an outer phase containing
- c2) a disintegrant,
- d2) a wicking agent, and,
- e) optionally, further excipients.
7 more elements
Dependencies are inferred from the claim text.