Synthetic Lactone Formulations and Method of Use
AssigneeMagnachem International Laboratories, Inc.
InventorsFederico M. Gomez, C. Federico Garcia Gomez-Godoy
Life of this patent
Estimating the term…
Abstract
Natural and synthetic compounds having a lactone structure methods for alleviation of pain, especially pain associated with disorders such as melanoma, leukemia, breast cancer, lung cancer, ovarian cancer, colon cancer, esophagus cancer, liver cancer, and lymphatic cancer. Initial studies have shown that patients can be taken off of morphine when the preferred alpha-methylene-gamma-butyrolactone is administered in a dosage of between 60 and 120 mg/day intramuscularly.
Claims17
A dosage formulation comprising a lactone compound or a pharmaceutically acceptable salt or hydrate thereof wherein the lactone compound has one of the following structures:
- wherein R1-R6 taken independently are a hydrogen atom or a group or grouping selected from the group consisting of alkyl, substituted alkyl, ally, substituted allyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, halo, hydroxyl, alkoxy, substituted alkoxy, alloxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, sulfonyl, substituted sulfonyl, sulfonic acid, phosphoryl, substituted phosphoryl, phosphonyl, substituted phosphonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, aminoacid, peptide, and polypeptide groups, excluding R3 or R4 being substituted phenyl in Formula Ia;
- Z is a heteroatom selected from the group consisting of oxygen, sulfur, and nitrogen groupings in linear, branched, or cyclic structural formats;
- and
- X is a heteroatom selected from the group consisting of oxygen, sulfur, and nitrogen groupings in linear, branched, or cyclic structural formats, and a pharmaceutically acceptable carrier,
- wherein the lactone is in an effective amount to alleviate pain.
A method of treating pain comprising administering to an animal a composition comprising an effective amount of a compound or a pharmaceutically acceptable salt or hydrate thereof in a pharmaceutically acceptable carrier, to alleviate pain, wherein the compound has one of the following the following structures:
- wherein R1-R6 taken independently are a hydrogen atom or a group or grouping selected from the group consisting of alkyl, substituted alkyl, ally, substituted allyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, phenyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, halo, hydroxyl, alkoxy, substituted alkoxy, alloxy, phenoxy, substituted phenoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, phenylthio, substituted phenylthio, arylthio, substituted arylthio, cyano, isocyano, substituted isocyano, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, sulfonyl, substituted sulfonyl, sulfonic acid, phosphoryl, substituted phosphoryl, phosphonyl, substituted phosphonyl, polyaryl, substituted polyaryl, C1-C20 cyclic, substituted C1-C20 cyclic, heterocyclic, substituted heterocyclic, aminoacid, peptide, and polypeptide groups, excluding R3 or R4 being substituted phenyl in Formula Ia;
- Z is a heteroatom selected from the group consisting of oxygen, sulfur, and nitrogen groupings in linear, branched, or cyclic structural formats;
- and
- X is a heteroatom selected from the group consisting of oxygen, sulfur, and nitrogen groupings in linear, branched, or cyclic structural formats.
Dependencies are inferred from the claim text.