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US 2012/0142731 A1Published application
Methods of inhibiting viral infection
AssigneeFunctional Genetics, Inc.
InventorsMichael Kinch, Michael Goldblatt
Life of this patent
Estimating the term…
Abstract
Compounds, pharmaceutical compositions and methods of inhibiting viral infection in a mammal in need of same, are provided, which employ compounds of the formula wherein each X is independently H or an electrodonating group, each Y is independently H, alkyl of 1-4 carbon atoms, hydroxy, alkoxy or methylene and wherein Substituent Z is a di-or-tri akly amino, or alkyl di or tri amino, optionally substituted with a halogen moiety. This family of compounds, designated FGI-104 herein, inhibits viral infection therapeutically and prophylactically.
Claims16
A compound of the formula
- wherein each substituent X is independently H or an electron donating group, which may be selected from the group including chloro chloro or other halogen, hydroxy, alkoxy (—OR), aryloxy (—OAr), trialkylammonium (—NR3+), alkylamido (—NHCOR, —NRCOR′), arylamido (—NHCOAr, —NRCOAr, —NArCOAr), arylcarbamoyl (—NHCOOAr, —NRCOOAr), alkylcarbamoyl (—NHCOOR, —NRCOOR′), cyano (—CN), nitro (—NO2), ester (—COOR, —COOAr), or alkyl halo, each substituent Y is independently H, alkyl of 1-4 carbon atoms, hydroxy, alkoxy oe methylene and wherein
- substituent Z is a di-or-tri akly amino, or alkyl di or tri amino, optionally substituted with a halogen moiety,
- further wherein said compound, when administered in effective amounts to a mammalian cell infected with a virus, inhibits viral infection and replication in said cell without cytotoxic effects for said cell.
Dependencies are inferred from the claim text.