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AssigneeThe General Hospital Corporation
InventorsShelley I. Fried, Daniel K. Freeman
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The present invention provides for a method of selectively activating synaptically mediated responses in ganglion cells without activating passing axons, by contacting a focal region around said cells with an electrode that stimulates using low-frequency sinusoidal electric signal. In particular, the selective low-frequency sinusoidal stimulation has a frequency of ≦25 Hz. specific frequencies of sinusoidal stimulation, which can be used to preferentially activate certain neural cell types, including retinal cells: ganglion cells at 100 Hz, photoreceptors are activated at 5 Hz, and bipolar cells at 25 Hz.
A method of selectively activating synaptically mediated responses in ganglion cells without activating passing axons, comprising contacting a focal region around said cells with an electrode that stimulates using low-frequency sinusoidal electric signal.
A method of selectively activating cells comprising exposing said cells to a low frequency sinusoidal electric signal of about ≦100 Hz.
Dependencies are inferred from the claim text.