Modulation of inflammatory responses by factor xi
AssigneeIsis Pharmaceuitcals, inc.
InventorsBrett P. Monia, Jeffrey R. Crosby, Robert A. MacLeod, Susan M. Freier
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Abstract
Disclosed herein are antisense compounds and methods for modulating Factor XI and modulating an inflammatory disease, disorder or condition in an individual in need thereof. Inflammatory diseases in an individual such as arthritis and colitis can be ameliorated or prevented with the administration of antisense compounds targeted to Factor XI.
Claims38
A method for modulating an inflammatory response by administering a compound to an animal, wherein the compound comprises a Factor XI modulator and whereby the inflammatory response is modulated in the animal.
A method for ameliorating or reducing the risk of an inflammatory disease, disorder or condition in an animal, or for treating an animal at risk for an inflammatory disease, disorder or condition, comprising administering a compound targeting Factor XI to the animal, wherein the compound administered to the animal ameliorates or reduces the risk of the inflammatory disease, disorder or condition in the animal, or treats the animal at risk for the inflammatory disease, disorder or condition.
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A method for inhibiting Factor XI expression in an animal suffering from an inflammatory disease, disorder or condition, comprising administering a compound targeting Factor XI to the animal, wherein the compound administered to the animal inhibits Factor XI expression in the animal suffering from the inflammatory disease, disorder or condition.
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Dependencies are inferred from the claim text.