Cyclopamine lactam analogs and methods of use thereof

A compound of the formula:

• or a pharmaceutically acceptable salt thereof.

A pharmaceutical composition comprising a compound of the formula:

• or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient.

A method of treating cancer, which comprises administering to a subject in need thereof a therapeutically effective amount of a compound of the formula:

• or a pharmaceutically acceptable salt thereof;
• wherein the cancer is selected from the group consisting of acute lymphocytic leukemia, acute myelocytic leukemia, basal cell carcinoma, bile duct carcinoma, bladder carcinoma, breast cancer, chondrosarcoma, chronic lymphocytic leukemia, chronic myeloid leukemia, colon cancer, esophageal cancer, gastric cancer, gastrointestinal stromal tumor, glioma, hepatocellular cancer, Hodgkin's disease, leukemia, lung cancer, medulloblastoma, melanoma, multiple myeloma, myelodysplastic syndrome, neuroectodermal tumors, non-Hodgkin's type lymphoma, osteogenic sarcoma, ovarian cancer, pancreatic cancer, prostate cancer, sarcoma, and testicular cancer.