Crystalline oxalate salts of a diamide compound
AssigneeTheravance, Inc.
InventorsMiroslav RAPTA, Venkat THALLADI, Robert S. CHAO
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Abstract
The invention relates to crystalline oxalate salts of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]-methyl}phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester. This invention also relates to compositions containing such a crystalline oxalate salt; methods of using such a crystalline oxalate salt to, for example, treat a pulmonary disorder; and to processes for preparing such a crystalline oxalate salt.
Claims16
A crystalline oxalate salt of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-{[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethylamino]methyl}-phenylcarbamoyl)butyl]methylcarbamoyl}ethyl)piperidin-4-yl ester;
- wherein the crystalline oxalate salt is selected from:
- (a) an isopropanol solvate characterized by a powder x-ray diffraction pattern comprising diffraction peaks at 20 values of 11.66±0.20, 15.75±0.20, 19.55±0.20, 23.00±0.20 and 23.45±0.20;
- and
- (b) a hydrate characterized by a powder x-ray diffraction pattern comprising diffraction peaks at 2θ values of 15.32±0.20, 16.90±0.20, 19.25±0.20 and 23.73±0.20.
Dependencies are inferred from the claim text.