Novel Compounds, Pharmaceutical Compositions Containing Same, Methods of Use for Same, and Methods for Preparing Same

A compound comprising a formula I:

• wherein
• n is either 0 or 1;
• A is selected from the group consisting of NR1, O, and S, wherein le is selected from the group consisting of H, hydroxyl, C1-C10 alkyl, C1-C10 alkoxy, alkenyl, aryl, alkylaryl and arylalkyl;
• X is selected from the group consisting of a carboxylate residue, a phosphonate residue, a phosphate residue, and a C1-C10 alkyl residue which is optionally substituted with one or more residues selected from the group consisting of a carboxylate residue, a phosphonate residue and a phosphate residue;
• Y is selected from the group consisting of C1-C20 alkyl, alkenyl, halide, hydroxyl, C1-C20 alkoxy, aryl, alkylaryl, arylalkyl, cycloalkyl, cycloalkenyl and a heterocyclic ring, any of which are optionally substituted at one or more positions with a halogen;
• and
• Z is selected from the group consisting of H, a hydroxyl group, a halide, an aryl group, an alkylaryl group, an arylalkyl group, a cycloalkyl group, a cycloalkenyl group and a heterocyclic ring, any of which are is optionally substituted at one or more positions with one or a combination of substitution groups selected from the group consisting of a C1-10 alkyl group, C1-10 alkoxy group, a hydroxyl group, a cyano group, a carboxylate group, a halide, an aryl group, an alkylaryl group, an arylalkyl group, a cycloalkyl group, a cycloalkenyl group and a heterocyclic ring.

A compound comprising a formula IVa:

• wherein
• n is 0;
• A is selected from the group consisting of NR1, O, and S, wherein R1 is selected from the group consisting of H, hydroxyl, C1-C10 alkyl, C1-C10 alkoxy, alkenyl, aryl, alkylaryl and arylalkyl;
• Y is selected from the group consisting of C1-C20 alkyl, alkenyl, halide, hydroxyl, C1-C20 alkoxy, aryl, alkylaryl, arylalkyl, cycloalkyl, cycloalkenyl and a heterocyclic ring, any of which are optionally substituted at one or more positions with a halogen;
• and
• Z is selected from the group consisting of H, a hydroxyl group, a halide, an aryl group, an alkylaryl group, an arylalkyl group, a cycloalkyl group, a cycloalkenyl group and a heterocyclic ring, any of which are optionally substituted at one or more positions with one or a combination of substitution groups selected from the group consisting of a C1-10 alkyl group, C1-10 alkoxy group, a hydroxyl group, a cyano group, a carboxylate group, a halide, an aryl group, an alkylaryl group, an arylalkyl group, a cycloalkyl group, a cycloalkenyl group and a heterocyclic ring.