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US 2012/0083444 A1Published application
Emulsion Method For Preparing Low Residual Solvent Microparticles
OwnerBrenda Perkins, Asima Pattanaikinventors
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Abstract
The method disclosed herein comprises using a non-polar alkane in the continuous phase of an emulsion process to aid in the removal of dispersed phase solvent from the microparticles. The microparticles can further be subjected to a post-production treatment process, involving a non-polar alkane suspension and a rinse, to further reduce residual dispersed phase solvent levels.
Claims25
An emulsion, comprising:
- a dispersed phase, comprising:
- a biocompatible polymer dispersed or dissolved in a dispersed phase solvent comprising a C1-C4 halogenated alkane, ethyl acetate, or a combination thereof;
- and
- a continuous phase, comprising:
- a surfactant mixture and a non-polar alkane;
- wherein the surfactant mixture comprises at least 2% by weight of the non-polar alkane dissolved or dispersed therein;
- wherein the dispersed phase is dispersed in the continuous phase.
4 more elements
A method for preparing microparticles, comprising:
- (a) providing a first phase comprising a biocompatible polymer dispersed or dissolved in a dispersed phase solvent comprising a C1-C4 halogenated alkane, ethyl acetate, or a combination thereof;
- (b) providing a second phase comprising a continuous phase surfactant mixture and a non-polar alkane;
- wherein the surfactant mixture comprises at least 2% by weight of the non-polar alkane dissolved or dispersed therein;
- (c) mixing the first and second phases to form an emulsion;
- and
- (d) removing at least a portion of the dispersed phase solvent to form microparticles.
3 more elements
Dependencies are inferred from the claim text.