Myostatin binding agents

A binding agent comprising at least one peptide capable of binding myostatin, wherein the peptide comprises the sequence Cb1b2Wb3WMCPP (SEQ ID NO:

• 353), wherein
• b1 is selected from any one of the amino acids T, I, or R;
• b2 is selected from any one of R, S, Q;
• b3 is selected from any one of P, R and Q,
• and wherein the peptide is between 10 and 50 amino acids in length, and physiologically acceptable salts thereof.

A binding agent comprising at least one peptide capable of binding myostatin, wherein the peptide is selected from the group consisting of:

• (a) a peptide comprising the amino acid sequence WYe1e2Ye3G, (SEQ ID NO:
• 356), wherein e1 is P, S or Y, e2 is C or Q, and e3 is G or H;
• (b) a peptide comprising the amino acid sequence f1EMLf2SLf3f4LL, (SEQ ID NO:
• 455), wherein f1 is M or I, f2 is any amino acid, f3 is L or F, and f4 is E, Q or D;
• (c) a peptide comprising the amino acid sequence Lg1g2LLg3g4L, (SEQ ID NO:
• 456), wherein g1 is Q, D or E, g2 is S, Q, D or E, g3 is any amino acid, and g4 is L, W, F, or Y;
• and
• (d) a peptide comprising the amino acid sequence h1h2h3h4h5h6h7h8h6 (SEQ ID NO:
• 457), wherein h1 is R or D, h2 is any amino acid, h3 is A, T S or Q, h4 is L or M, h5 is L or S, h6 is any amino acid, h7 is F or E, h8 is W, F or C, and h9 is L, F, M or K,
• and physiologically acceptable salts thereof.

A binding agent wherein said agent has the structure:

• (X1)a—F1—(X2)b, or multimers thereof;
• wherein F1 is a vehicle;
• and X1 and X2 are each independently selected from
• -(L1)c-P1;
• -(L1)c-P1-(L2)d-P2;
• -(L1)c-P1-(L2)d-P2-(L3)e-P3;
• and -(L1)c-P1-(L2)d-P2-(L3)e-P3-(L4)f-P4;
• wherein P1, P2, P3, and P4 are peptides capable of binding myostatin, wherein L1, L2, L3, and L4 are each linkers;
• and a, b, c, d, e, and f are each independently 0 or 1, provided that at least one of a and b is 1, and physiologically acceptable salts thereof.

A binding agent wherein said agent has the structure:

• (X1)a—F1—(X2)b, or multimers thereof
• wherein F1 is a vehicle;
• and X1 and X2 are each independently selected from
• -(L1)c-P1;
• -(L1)c-P1-(L2)d-P2;
• -(L1)c-P1-(L2)d-P2-(L3)e-P3;
• and -(L1)c-P1-(L2)d-P2-(L3)e-P3-(L4)f-P4;
• wherein P1, P2, P3, and P4 are peptides capable of binding myostatin, and are independently selected from SEQ ID NO:
• 305 through 351 and SEQ ID NO:
• 357 through 454;
• wherein L1, L2, L3, and L4 are each linkers;
• and a, b, c, d, e, and f are each independently 0 or 1, provided that at least one of a and b is 1, and physiologically acceptable salts thereof.

A binding agent capable of binding myostatin comprising the structure F1-(L1)-P1, wherein F1 is a human IgG Fc, wherein L1 is (Gly)5, wherein the binding agent further comprises AQ and wherein P1 is selected from SEQ ID NO:

• 311, SEQ ID NO:
• 325, SEQ ID NO:
• 326, SEQ ID NO:
• 336, SEQ ID NO:
• 337, and SEQ ID NO:
• 345.