Method of Preparing Water-Soluble and Biodegradable Antimicrobial Agent

A method of preparing a biodegradable antimicrobial agent, comprising:

• (a) forming an aqueous polypeptide solution by dissolving a polypeptide into an aqueous solution;
• (b) providing an aqueous sodium hypochlorite solution;
• (c) adding the aqueous sodium hypochlorite solution into the aqueous polypeptide solution to form a mixture;
• and
• (d) mixing the mixture for at least 1 min, such that the polypeptide compound reacts with sodium hypochlorite in the aqueous sodium hypochlorite solution, thereby forming a polypeptide chloride having at least one N-halamine group of N—Cl,
• wherein, the polypeptide compound is a polyglutamic acid or polyaspartic acid, and the polypeptide chloride is a polyglutamic acid chloride or polyaspartic acid chloride.