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US 2012/0075457 A1Published application
Fully Automatic Rapid Microscope Slide Scanner
AssigneeAperio Technologies, Inc.
InventorDirk G. Soenksen
Life of this patent
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Abstract
Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image.
Claims9
A microscope slide scanner for creating a contiguous digital image of an entire microscope microscope sample, comprising:
- a motorized stage configured to support a microscope sample and move the microscope sample at a substantially constant velocity;
- at least one objective lens positioned for viewing at least a portion of the microscope sample;
- at least one line scan camera optically coupled to the objective lens, the line scan camera having a linear field of view defined by a plurality of pixel elements arranged in at least one linear array;
- at least one focusing optics whereby an optical signal from the objective lens is focused onto the plurality of pixel elements of the at least one line scan camera;
- a data processor configured to synchronize velocity of the microscope sample with a line rate of the at least one line scan camera to digitize a plurality of contiguous linear fields of view and store in a memory said plurality of contiguous linear fields of view as a digital image strip, wherein a digital image strip comprises at least 30,000 contiguous linear fields of view, the data processor further configured to assemble a plurality of digital image strips into a contiguous digital image of an entire microscope sample and store the contiguous digital image.
2 more elements
Dependencies are inferred from the claim text.