Methods of predicting complication and surgery in crohn's disease
AssigneeCedars-Sinai Medical Center
InventorsJerome I. Rotter, Kent D. Taylor, Marla Dubinsky, Stephan R. Targan
Life of this patent
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Abstract
The present invention relates to prognosing, diagnosing and treating an aggressive form of Crohn's disease characterized by rapid progression to complication and/or surgery from the time of diagnosis. In one embodiment, the prognosis, diagnosis and treatment is based upon the presence of one or more genetic risk factors.
Claims29
A method of prognosing Crohn's disease in an individual, comprising:
- obtaining a sample from the individual;
- assaying the sample for the presence or absence of one or more genetic risk variants;
- and
- prognosing an aggressive form of Crohn's disease based on the presence of one or more genetic risk variants,
- wherein the one or more genetic risk variants are selected from the genetic loci of 8q24, 16p11, Bromodomain and WD repeat domain containing 1 (BRWD1) and/or Tumor necrosis factor superfamily member 15 (TNFSF15).
A method of prognosing Crohn's disease in an individual, comprising:
- obtaining a sample from the individual;
- assaying the sample for the presence or absence of one or more genetic risk variants;
- and
- prognosing a form of Crohn's disease associated with a complication based on the presence of one or more genetic risk variants,
- wherein the one or more genetic risk variants is selected from the group consisting of SEQ. ID. NO.:
- 7, SEQ. ID. NO.:
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- 21, and/or SEQ. ID. NO.:
- 22.
A method of prognosing Crohn's disease in an individual, comprising:
- obtaining a sample from the individual;
- assaying the sample for the presence or absence of one or more genetic risk variants;
- and
- prognosing a form of Crohn's disease associated with one or more conditions that require a treatment by surgery;
- wherein the one or more genetic risk variants is selected from the group consisting of SEQ. ID. NO.:
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- 51, and/or SEQ. ID. NO.:
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A method of treating Crohn's disease in an individual, comprising:
- prognosing an aggressive form of Crohn's disease in the individual based on the presence of one or more genetic risk variants;
- and
- treating the individual,
- wherein the one or more genetic risk variants are selected from the genetic loci of 8q24, 16p11, Bromodomain and WD repeat domain containing 1 (BRWD1) and/or Tumor necrosis factor superfamily member 15 (TNFSF15).
A method of diagnosing susceptibility to Crohn's disease in an individual, comprising:
- obtaining a sample from the individual;
- assaying the sample for the presence or absence of one or more genetic risk variants;
- and
- diagnosing susceptibility to Crohn's disease in the individual based on the presence of one or more genetic risk variants,
- wherein the one or more genetic risk variants are located at the genetic loci of 8q24, 16p11, and/or Bromodomain and WD repeat domain containing 1 (BRWD1).
Dependencies are inferred from the claim text.