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US 2012/0073578 A1Published application
Low-dose transdermal patches with high drug release
AssigneeBayer Pharma Aktiengesellschaft
InventorsIldiko TEREBESI, Christian ZURTH, Hannes-Friedrich ULBRICH
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Abstract
The present invention relates to the field of pharmaceutical formulation techniques. The invention provides a low dosage pharmaceutical composition for transdermal delivery of hormones, preferably a progestin, such as a Gestodene, and an estrogen, preferably Ethinylestradiol so as to achieve plasma concentration profiles effective in inhibiting ovulation in a woman.
Claims25
Transdermal therapeutic system containing, in order:
- a) a backing layer,
- b) at least one drug-containing adhesive layer comprising the active ingredients Gestodene and Ethinylestradiol in a polyisobutylene-containing matrix and optionally other pharmaceutically acceptable ingredients, and
- c) a release liner;
- wherein the Gestodene amount is from about 0.4 to 1.95% by weight of the drug-containing layer and the Ethinylestradiol amount is about 0.5% (w/w) by weight of the drug-containing layer.
1 more element
Dependencies are inferred from the claim text.