Method For Enucleating Nucleated Erythrocyte, And Enucleation Inducer
AssigneeKanazawa Medical University
InventorsToshihisa Hatta, Eriko Shimamura, Hiroki Shimada
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Abstract
Provided is a factor capable of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time. More particularly, provided are a method of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time by adding a compound derived from proopiomelanocortin (POMC) to an undifferentiated (nucleated) erythrocyte, and an enucleation inducer including the compound.
Claims15
A method of enucleating a nucleated erythrocyte, comprising culturing a separated nucleated erythrocyte in a culture medium containing a compound derived from proopiomelanocortin (POMC).
An enucleation inducer, comprising a compound derived from POMC.
A method of culturing and/or proliferating an enucleated erythrocyte, comprising culturing a hematopoietic stem cell or an erythroid precursor cell in a culture medium containing a compound derived from POMC.
An enucleation inducer, wherein the enucleation inducer induces enucleation in vitro through an action on MC1R, MC2R, MC3R, MC4R, and/or MC5R, which is a melanocortin receptor expressed on a nucleated erythrocyte.
A method of enucleating a nucleated erythrocyte, comprising inducing enucleation in vitro through an action on MC1R, MC2R, MC3R, MC4R, and/or MC5R, which is a melanocortin receptor expressed on a nucleated erythrocyte.
Dependencies are inferred from the claim text.