Dna vaccines encoding heat shock proteins
AssigneesProf. Irun R. Cohen, Felix Mor, Pnina Carmi, Dr. Francisco Quintana
InventorsIrun R. Cohen, Francisco J. Quintana, Pnina Carmi, Felix Mor
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Abstract
The present invention is related to a method of treating a T cell-mediated inflammatory autoimmune disease by administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 60 (HSP60), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences, and wherein the disease is other than insulin dependent diabetes mellitus (IDDM), thereby treating the disease.
Claims22
A method of treating a T cell-mediated inflammatory autoimmune disease, which comprises administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding heat shock protein 60 (HSP60), or an active fragment thereof, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences, and wherein the disease is other than insulin dependent diabetes mellitus (IDDM), thereby treating the disease.
A method of treating a T cell-mediated inflammatory autoimmune disease, which comprises administering to an individual in need thereof an immunogenic composition comprising a recombinant construct of a nucleic acid sequence encoding a heat shock protein (HSP), or an active fragment thereof, wherein the heat shock protein is selected from the group consisting of HSP70 and HSHP90, wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences, thereby treating the disease.
An immunogenic composition for treating a T cell-mediated inflammatory autoimmune disease, the composition comprising a recombinant construct of a nucleic acid sequence encoding a heat shock protein (HSP), or an active fragment thereof, wherein the heat shock protein is selected from the group consisting of HSP60, HSP 70 and HSP90, and a pharmaceutically acceptable carrier;
- wherein the nucleic acid sequence is operatively linked to one or more transcription control sequences in a suitable expression system.
Dependencies are inferred from the claim text.