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US 2012/0059161 A1Published application
Compounds and methods for treating aids and hiv infections
AssigneePurdue Research Foundation
InventorArun K. Ghosh
Life of this patent
Estimating the term…
Abstract
Macrocycle containing carbamate compounds that inhibit HIV proteolytic enzymes and processes for preparing them are described. Compositions and methods for treating a patient infected with HIV are described.
Claims21
A compound of the formula
- or a pharmaceutically acceptable salt thereof;
- wherein
- R2 and R3 are in each instance independently selected from the group consisting of hydrogen and a prodrug forming group;
- R5 is alkyl, alkenyl, heteroalkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each of which is optionally substituted;
- X4 is carbonyl, S(O) or SO2;
- X5 is a bond, oxygen, unsubstituted nitrogen, substituted nitrogen, sulfur, S(O) or sulfone;
- L1 and L2 are independently selected in each instance from the group consisting of alkylene, cycloalkylene, unsaturated alkylene, heteroalkylene, cycloheteroalkylene, and unsaturated heteroalkylene, each of which is optionally substituted;
- W is a bond, (H)C═C(H), oxygen, sulfur, S(O), SO2, C(O), or optionally substituted nitrogen;
- Q2 is a divalent carbocyle, heterocycle, aryl, or heteroaryl, each of which is optionally substituted with one or more substituents;
- and
- Z is selected from the group consisting of monocyclic heterocycle, bicyclic heterocycle and tricyclic heterocycle, each of which is optionally substituted.
8 more elements
The compound of claim 2 or 35 wherein X4 is S(O)2.
-40. (canceled)
Dependencies are inferred from the claim text.